武晶晶;刘晓雪;李传彬;张先慧;宋凯军;赵小冬;

• 1:济南市疾病预防控制中心

摘要(Abstract)：

目的分析济南市2012-2016年急性脑炎脑膜炎症候群(Acute meningitis and encephalitis syndrome,AMES)监测病例的病原谱。方法选择济南市6家监测医院,采集AMES病例的血清/脑脊液(CSF)标本,采用ELISA检测乙脑病毒(JEV)、水痘-带状疱疹病毒(VZV)、麻疹病毒(MV)、人类肠道病毒(HEV)、巨细胞病毒(CMV)、单纯疱疹病毒(HSV)、风疹病毒(RV)和腮腺炎病毒(MuV)IgM抗体,采用PCR检测脑膜炎奈瑟菌(Nm)、肺炎链球菌(Sp)和b型流感嗜血杆菌(Hib)抗原,对数据进行描述性分析。结果 2012-2016年共报告AMES病例4 550例,其中4 122例血清/CSF标本JEV的IgM抗体阳性率为8.6%;3 750例血清标本HEV、HSV、MuV、VZV、MV、RV、CMV的IgM抗体阳性率分别为17.1%、22.0%、8.5%、0.1%、0.1%、0.5%、0.6%;2 864例CSF标本Nm、Sp、Hib的PCR抗原检测阳性率分别为2.3%、1.1%、0.1%。结论济南市2012-2016年AMES病例的优势致病原为HSV、HEV、JEV和MuV。

关键词(KeyWords)： 急性脑炎脑膜炎症候群;病原谱;监测

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 武晶晶;刘晓雪;李传彬;张先慧;宋凯军;赵小冬;

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