朱琦,吴承刚,邵晓萍,梁剑,孙立梅,梁文佳,郑慧贞

• 1:广东省疾病预防控制中心

摘要(Abstract)：

目的评价18-23月龄儿童甲型肝炎(甲肝)减毒活疫苗(HepA-L)、麻腮风联合减毒活疫苗(MMR)单独和同时接种的免疫效果。方法采用多中心、随机、对照设计,招募无甲肝疫苗免疫史且完成首剂次含麻疹成分疫苗的18-23月龄儿童,随机分为3组,分别接种HepA-L、HepA-L与MMR、MMR,检测每名儿童免疫前、免疫后1个月血清甲肝、麻疹、腮腺炎、风疹IgG抗体,分析免疫后抗体阳性率和阳转率。结果 HepA-L组儿童免疫后甲肝抗体阳性率、阳转率分别为81.3%(148/182)、80.3%(139/173)。MMR+HepA-L组儿童免疫后麻疹、风疹、腮腺炎、甲肝抗体阳性率分别为98.3%(178/181)、92.3%(167/181)、78.5%(142/181)、77.9%(147/181),阳转率分别为90.0%(9/10)、86.7%(26/30)、78.2%(129/165)、75.5%(123/163)。MMR组儿童免疫后麻疹、风疹、腮腺炎抗体阳性率分别为94.0%(157/167)、84.4%(141/167)、77.2%(129/167),阳转率分别为87.5%(14/16)、83.7%(36/43)、78.3%(123/157)。结论 18-23月龄儿童单独和同时接种HepA-L和MMR均具有良好的免疫效果;同时接种对各疫苗成分的免疫效果没有影响。

关键词(KeyWords)： 甲型肝炎减毒活疫苗;麻腮风联合减毒活疫苗;同时接种;免疫原性

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 朱琦,吴承刚,邵晓萍,梁剑,孙立梅,梁文佳,郑慧贞

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