叶家楷,李克莉,许涤沙,武文娣,郑景山,曹雷,曹玲生,崔健,刘大卫,王华庆

• 1:中国疾病预防控制中心免疫规划中心

摘要(Abstract)：

目的分析中国(未包括香港、澳门特别行政区和台湾地区,下同)2015年疑似预防接种异常反应(Adverse events following immunization,AEFI)监测质量和发生特征。方法通过中国免疫规划信息管理系统收集2015年发生的AEFI个案和疫苗接种数据,采用描述性流行病学方法进行分析。结果 2015年中国共报告154 223例AEFI;94.81%的县(区、市、旗)有AEFI报告;48h内报告率为98.80%;48h内调查率为98.29%。在报告病例中,男、女性别比为1.28:1;≤2岁占81.38%;东部、中部和西部地区分别占45.82%、36.06%、18.12%;98.06%的AEFI发生在接种后2d内;一般反应、异常反应分别占92.07%、6.61%。AEFI总估算报告发生率为29.74/10万剂;一般反应、异常反应、严重异常反应报告发生率分别为27.38/10万剂、1.97/10万剂、0.11/10万剂。异常反应主要为过敏性皮疹(8 202例,1.58/10万剂)、卡介苗淋巴结炎(343例,2.23/10万剂)、血管性水肿(331例,0.06/10万剂)、热性惊厥(212例,0.04/10万剂)、卡介苗局部脓肿(121例,0.79/10万剂)。结论 2015年中国AEFI监测敏感性和质量继续保持高水平。需继续加强尤其是中、西部薄弱地区AEFI监测管理和严重AEFI风险评估与处置工作。

关键词(KeyWords)： 疑似预防接种异常反应;监测

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 叶家楷,李克莉,许涤沙,武文娣,郑景山,曹雷,曹玲生,崔健,刘大卫,王华庆

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