吴丹,尹遵栋,李军宏,施文,王环宇,付士红,李艺星

• 1:中国疾病预防控制中心免疫规划中心
• 2:营口市疾病预防控制中心
• 3:中国疾病预防控制中心病毒病预防控制所

摘要(Abstract)：

目的分析中国2014-2018年流行性乙型脑炎(乙脑)流行病学特征。方法通过中国疾病预防控制信息系统和乙脑监测信息报告管理系统收集2014-2018年乙脑病例,进行描述性流行病学分析。结果中国2014-2018年共报告乙脑5 666例,年均发病率为0.083/10万;死亡309例,病死率为5.45%。年均发病率居前5位的省份为甘肃(0.76/10万)、宁夏(0.50/10万)、陕西(0.31/10万)、云南(0.23/10万)和四川(0.17/10万)。7-9月份病例数占90.31%。0-14岁、15-39岁、≥40岁病例分别占42.53%、14.83%、42.64%,其中≥40岁病例构成比从2014年的14.45%上升至2018年的64.04%,0-4岁、5-9岁乙脑发病率分别从2014年的0.28/10万、0.36/10万降至2018年的0.11/10万、0.17/10万;≥40岁各年龄组发病率均上升。在4 007例随访病例中,痊愈、好转、有后遗症、死亡分别占48.91%、18.27%、16.45%、16.37%,其中≥40岁病例中死亡占26.70%。结论中国2014-2018年儿童乙脑发病率持续下降。建议在成人乙脑高发地区开展乙脑疫苗接种和相关研究,持续开展蚊种密度和健康人群乙脑抗体水平监测。

关键词(KeyWords)： 流行性乙型脑炎;流行病学特征

Abstract:

Keywords:

基金项目(Foundation): 中国CDC公共卫生应急反应机制的运行（131031001000150001）

作者(Author): 吴丹,尹遵栋,李军宏,施文,王环宇,付士红,李艺星

参考文献(References)：

• [1] TOM S. Cont rol of Japanese encephalitis--within our grasp?[J]. New England Journal of Medicine, 2006, 355(9):869-871.
• [2] FISCHER M, CASEY C, CHEN RT. Promise of new Japanese encephalitis vaccines[J]. The Lancet, 2007,370(9602):1806-1808.
• [3]王国强.中国疾病预防控制60年[M].北京:中国人口出版社, 2015. WANG Guoqiang, A 60-year history of disease prevention and control in China[M]. China Population Publishing House, 2015.
• [4] World Health Organization. Japanese encephalitis vaccines:WHO position paper–February[J]. WER, 2015, 90(9):69-88.
• [5] BAE W, KIM JH, KIM J, et al. Changes of epidemiological characteristics of Japanese encephalitis viral infection and birds as a potential viral transmitter in Korea[J]. Journal of Korean Medical Science, 2018, 33(9):e70.
• [6]尹遵栋,梁晓峰,李艺星,等.运城市2006年流行性乙型脑炎疫情调查分析[J].中国计划免疫, 2007, 13(3):270-273. YIN Zundong, LIANG Xiaofeng, LI Yixing, et al.Investigation and analysis on the Japanese B encephalitis epidemic in Yuncheng pref ecture, Shanxi province,2006[J]. Chinese Journal of Vaccines and Immunization,2007, 13(3):270-273.
• [7] World Health Organization. Japanese encephalitis[EB/OL].(2019-05-09)[2019-10-21]. https://www.who.int/en/news-room/fact-sheets/detail/japanese-encephalitis.
• [8]吴丹,宁桂军,尹遵栋,等.中国2011~2013年流行性乙型脑炎流行病学特征分析[J].中国疫苗和免疫, 2015, 21(5):486-490. WU Dan, NING Gui jun, YIN Zundong, et al.Epidemiological characteristics of Japanese encephalitis in China, 2011~2013[J]. Chinese Journal of Vaccines and Immunization, 2015, 21(5):486-490.
• [9]吴海霞,刘起勇.全球气候变暖对媒介生物性传染病的影响[C]//中国疾病预防控制中心第一届气候变化与健康论坛论文集, 2010:50-53. WU Haixia, LIU Qiyong. The impact of global warming on vector-borne disease[C]//Proceedings of the f irst climate change and health forum of Chinese Center for Disease Control and Prevention, 2010:50-53.
• [10]马玉霞,王娟怀,张军,等.气象因素与流行性乙型脑炎发病的关系[C]//第32届中国气象学会年会论文集,2015:1-11. MA Yuxia, WANG Juanhuai, ZHANG Jun, et al. The relationship between meteorological factors and encephalitis B[C]//Proceedings of the 32nd annual meeting of the Chinese meteorological society, 2015:1-11.
• [11] LI B, MORTON LC, LIU Q. Climate change and mosquitoborne diseases in China:a review[J]. Global Health, 2013,9:10.
• [12]张少白,李平,刘西珍,等.流行季节前后流行性乙型脑炎病毒中和抗体及隐性感染和显性感染比值分析[J].中华疾病控制杂志, 2012, 16(3):222-225. ZHANG Shaobai, LI Ping,LIU Xizhen, et al. Analysis on Japanese B encephalitis virus neutralization antibody titer in health people before and af ter epidemic season and the ratio of unapparent infection and apparent infection[J]. Chinese Journal of Disease Control&Prevention, 2012, 16(3):222-225.
• [13]唐晓燕,康锴,尚思远,等.河南省2010年流行性乙型脑炎病例及健康人群乙脑抗体水平监测[C]//第三届传染病防控基础研究与应用技术论坛论文集, 2012:314-320. TANG Xiaoyan, KANG Kai, SHANG Siyuan, et al. Surveillance of Japanese encephalitis and antibody levels in healthy population in Henan province in 2010[C]//Proceedings of the 3rd basic research and application technology forum for prevention and control of inf ectious diseases, 2012:314-320.
• [14]张少白,李平,刘西珍,等.陕西省健康人群流行性乙型脑炎病毒中和抗体检测分析[J].中国疫苗和免疫, 2010,16(3):251-253+257. ZHANG Shaobai, LI Ping, LIU Xizhen, et al. Analysis on neutralization antibody titer of Japanese B encephalitis virus in healthy population in Shaanxi province[J]. Chinese Journal of Vaccines and Immunization, 2010, 16(3):251-253+257.
• [15]刘立,王环宇,张世勇,等. 2013年石家庄市流行性乙型脑炎暴发疫情的流行病学分析[J].中国全科医学, 2016,19(29):3580-3583. LIU Li, WANG Huanyu, ZHANG Shiyong, et al. Epidemiological analysis of Japanese encephalitis outbreak in Shi jiazhuang city in 2013[J].Chinese General Practice, 2016, 19(29):3580-3583.
• [16] SUNWOO JS, JUNG KH, LEE ST, et al. Reemergence of Japanese encephalitis in South Korea, 2010-2015[J].Emerg Infect Dis, 2016, 22(10):1841-1843.
• [17] XIONG W, LU L, XIAO Y, et al. Mortality and disability due to Japanese encephalitis in elderly adults:evidence f rom an adult tertiary care center in west China[J]. Front Neurol, 2019, 10:918.