中国疫苗和免疫

目的了解广东省医院就诊人群破伤风IgG抗体水平。方法在广东省19个地市23家医院选择就诊人群,采集血清标本,采用酶联免疫吸附试验检测破伤风IgG抗体,分析抗体保护率(抗体浓度≥0.10IU/mL)和几何平均浓度(GMC)。结果调查对象破伤风IgG抗体总保护率为67.78%(1 557/2 297),GMC为0.27 IU/mL。<10岁、≥10岁抗体保护率分别为82.41%、22.08%(χ2=703.28,P<0.001),GMC分别为0.47IU/mL、0.05IU/mL(t=30.44,P<0.001);调查对象年龄与破伤风IgG抗体浓度之间呈负相关(r=-0.44,P<0.001)。结论广东省医院就诊人群破伤风抗体水平随年龄增长而下降;≥20岁成人破伤风感染风险较大,建议该人群适时接种1剂含破伤风成分疫苗。

Objective To assess IgG a ntibod y levels against teta n us a mong pa tients of medical centers in Guangdong province. Methods We collected serum specimens f rom patients of 23 hospitals in 19 pref ectures of Guangdong. We tested f or tetanus IgG antibody using enzyme-linked immunosorbent assay to determine protection rates(IgG antibody concentration ≥0.10 IU/mL) and geometric mean concentrations(GMCs). Results The overall protection rate of tetanus IgG antibody among the subjects was 67.78%(1 557/2 297) with a GMC of 0.27 IU/mL. Protection rates for <10-and ≥10-year-olds were 82.41% and 22.08%(χ2=703.28, P<0.001) with GMCs of 0.47 and 0.05 IU/mL( t=30.44, P<0.001), respectively. IgG antibody level and age were negatively correlated(r=-0.44, P<0.001). Conclusions Tetanus anybody levels decreased with increasing age among medical-visiting population in Guangdong, showing a high risk of tetanus inf ection f or adults over 20 years old. We suggest adults receive one dose of tetanus toxoid at an appropriate time.